![]() ![]() Data analyses yielded rates of change before and after symptomatic onset of Alzheimer's disease, allowing the alignment of the ∼30-year age difference between the cohorts on a clinically meaningful anchor point, namely the participant age at symptomatic onset.īiomarker profiles were similar for both autosomal dominant Alzheimer's disease and late onset Alzheimer's disease. Imaging data and CSF samples were reprocessed as appropriate to guarantee uniform pipelines and assays. ![]() We compared brain MRI and amyloid PET data, as well as CSF concentrations of amyloid-β 42, amyloid-β 40, tau and tau phosphorylated at position 181, in 292 carriers of pathogenic variants for Alzheimer's disease from the Dominantly Inherited Alzheimer Network, with corresponding data from 559 participants from the Alzheimer’s Disease Neuroimaging Initiative. ![]() ![]() The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of ‘sporadic’ late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings and clinical trial results in autosomal dominant Alzheimer's disease to late onset Alzheimer's disease. ![]()
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